The focus of our research lies in synthetic organic as well as biomolecular and medicinal chemistry.
We develop new synthetic methods which are highly selective and efficient as well as ecologically and economically benign. Thus, we have introduced the concept of domino reactions
and used it in the synthesis of natural products as alkaloids, steroids, terpenes, antibiotics, cytotoxic compounds, spinosyns and carbohydrates. In
addition, also materials especially molecular switches are prepared using this approach. Domino reactions allow the formation of complex structures starting from simple
substrates in a straight forward way. Moreover, we have developed a highly selective procedure for the allylation of aldehydes and ketones to give enantiopure homo-allylic ethers.
|Development of selective and efficient as well as ecologically and economically benign synthetic methods and their use in the total synthesis of bioactive natural products and materials.|
|Design of a novel approach for a selective treatment of cancer using the antibody directed enzyme prodrug therapy (ADEPT) and the prodrug monotherapy (PMT) as well as antibody drug conjugates (ADCs).|
|L.F. Tietze, T. Eicher, U. Diederichsen, A. Speicher, N. Schützenmeister||Reactions and Syntheses in the Organic Chemistry Laboratory, 2nd Edition (completely revised and updated), Wiley-VCH, Weinheim 2015, (ISBN: 3-527-33814-4, ISBN-13: 978-3527338146).|
|L.F. Tietze (Ed.)||Domino Reactions: Concepts for Efficient Organic Synthesis, Wiley-VCH, Weinheim, 2014, (ISBN: 3-527-33432-7, ISBN-13: 978-3527334322).|
|L.F. Tietze, G. Brasche, K. Gericke||Domino Reactions in Organic Synthesis, Wiley-VCH, Weinheim 2006, (ISBN: 3-527-29060-5, ISBN-13: 978-3527290604).|