Enantioselektive Totalsynthese von Hirsutin durch eine Drei-Komponenten-domino-Knoevenagel/hetero-Diels-Alder-Reaktion
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Naturstoffe sind wichtige Leitsubstanzen für die Entwicklung von Arzneimitteln; so beruhen etwa 60 % der für die Krebstherapie
eingesetzten Verbindungen auf Naturstoffen. Allerdings werden häufig nicht die Naturstoffe selbst sondern deren Analoga und Derivate verwendet.
Im Rahmen unseres Vorhabens werden daher nicht nur Naturstoffe aus dem Bereich der Alkaloide, Steroide, Chromane, Terpene, Antibiotika, Spinosyne,
Kohlenhydrate und Zytostatika sondern auch entsprechende Analoga bearbeitet. Ein Schwerpunkt ist hierbei die Verwendung katalytischer Verfahren und von domino-Prozessen. Enantioselektive Totalsynthese von Hirsutin durch eine Drei-Komponenten-domino-Knoevenagel/hetero-Diels-Alder-Reaktion |
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Chem. Eur. J. 2007, 13, 8543-8563. |
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Eur. J. Org. Chem. 2007, 4563-4577. |
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Chem. Eur. J. 2007, 13, 9939-9947. |
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Arkivoc 2007, 12-21. |
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Synlett 2007, 485-487. |
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Org. Biomol. Chem. 2007, 5, 1191-1200. |
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Pure Appl. Chem. 2007, 79, 629-650. |
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Insecticide Spinosyn A. Angew. Chem. 2006, 118, 5137-5140;
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Arkivoc 2007, 12-21. |
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